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Molecular and cellular role of RNA-binding proteins in cardiac biology and disease

Louis, Lithin

Description

Conventional RNA-binding proteins (RBPs) regulate post-transcriptional gene expression, forming dynamic ribonucleoprotein complexes via their globular RNA-binding domains (RBDs). However, unbiased identification using RNA interactome capture detected multiple RBPs devoid of classical RBDs, exhibiting novel modes of RNA interaction. Cardiomyocyte interactome capture using the murine HL-1 cardiomyocyte cell line detected multiple such unconventional RBPs, notably a high representation of...[Show more]

CollectionsOpen Access Theses
Date published: 2022
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/265551
DOI: 10.25911/6F9W-3570

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