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Infarct-induced chronic heart failure increases bi-directional protein movement across the alveolocapillary barrier

De Pasquale, Carmine G; BERSTEN, Andrew; DOYLE, Ian R; Aylward, Phillip; Arnolda, Leonard


Chronic heart failure (CHF) is associated with adaptive structural changes at the alveolocapillary barrier that may be associated with altered protein permeability. Bidirectional protein movement across the barrier was studied in anesthetized rats with infarct-induced CHF by following 125I-labeled albumin (125I-albumin) flux into the alveoli and the leakage of surfactant protein (SP)-B from the alveoli into the circulation. Three groups were studied: controls [0% left ventricular (LV)...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: American Journal of Physiology: Heart and Circulatory Physiology
DOI: 10.1152/ajpheart.00875.2002


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