Structure of the Janus Protein Human CLIC2
Cromer, Brett A; Gorman, Michael A.; Hansen, Guido; Adams, Julian J.; Coggan, Marjorie; Littler, Dene R; Brown, Louise J.; Mazzanti, Michele; Breit, Samuel N.; Curmi, Paul; Dulhunty, Angela; Board, Philip; Parker, Michael William
Chloride intracellular channel (CLIC) proteins possess the remarkable property of being able to convert from a water-soluble state to a membrane channel state. We determined the three-dimensional structure of human CLIC2 in its water-soluble form by X-ray crystallography at 1.8-Å resolution from two crystal forms. In contrast to the previously characterized CLIC1 protein, which forms a possibly functionally important disulfide-induced dimer under oxidizing conditions, we show that CLIC2...[Show more]
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|Source:||Journal of Molecular Biology|
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