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Comparative Efficacy of Subtype AE Simian-Human Immunodeficiency Virus Priming and Boosting Vaccines in Pigtail Macaques

De Rose, Robert; Batten, Jane; Smith, Miranda Z.; Fernandez, Caroline S.; Peut, Viv; Thomson, Scott; Ramshaw, Ian; Coupar, Barbara E.H.; Boyle, David B; Venturi, Vanessa; Davenport, Tracey; Kent, Stephen J


Vaccination against AIDS is hampered by great diversity between human immunodeficiency virus (HIV) strains. Heterologous B-subtype-based simian-human immunodeficiency virus (SHIV) DNA prime and poxvirus boost vaccine regimens can induce partial, T-cell-mediated, protective immunity in macaques. We analyzed a set of DNA, recombinant fowlpox viruses (FPV), and vaccinia viruses (VV) expressing subtype AE HIV type 1 (HIV-1) Tat, Rev, and Env proteins and SIV Gag/Pol in 30 pigtail macaques. SIV...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.01727-06


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