Ikeda, Kaori; Bekkers, John
The fidelity of neurotransmission at synapses depends on the maintained availability of transmitter-filled synaptic vesicles (SVs) in the presynaptic terminal. The availability of SVs is in turn governed by the number of releasable vesicles in the presynaptic terminal and the rate at which these vesicles are recycled within the terminal. Thus, elucidating these two rate-limiting determinants of the SV cycle is essential for understanding the constraints on information transfer at synapses....[Show more]
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