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The domains carrying the opposing activities in adenylyltransferase are separated by a central regulatory domain

Clancy, Paula; Xu, Yibin; van Heeswijk, Wally C; Vasudevan, Subhash; Ollis, David


Adenylyltransferase is a bifunctional enzyme that controls the enzymatic activity of dodecameric glutamine synthetase in Escherichia coli by reversible adenylylation and deadenylylation. Previous studies showed that the two similar but chemically distinct reactions are carried out by separate domains within adenylyltransferase. The N-terminal domain carries the deadenylylation activity, and the C-terminal domain carries the adenylylation activity [Jaggi R, van Heeswijk WC, Westerhoff HV, Ollis...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: The FEBS Journal
DOI: 10.1111/j.1742-4658.2007.05820.x


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