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Long-term body weight outcomes of antidepressant-environment interactions

Mastronardi, Claudio; Da Paz Filho, Gilberto; Valdez, E; Maestre-Mesa, J; Licinio, Julio; Wong, Ma-Li


Both obesity rates and antidepressant use have escalated in the last 20 years. Most people who start antidepressant treatment discontinue it on their own. Meanwhile, obesity rates continue to increase. To test the hypothesis that antidepressant use is a risk factor for obesity, even after long-term discontinuation, we developed a novel animal paradigm consisting of short-term exposure to stress and antidepressants, followed by long-term high-fat diet. We show here that recurrent restraint...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Psychiatry
DOI: 10.1038/mp.2010.122


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