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Anti-neutrophil cytoplasmic antibody-associated systemic vasculitis: Nature or nurture?

Gatenby, Paul


This review examines the environmental and genetic contributions to the anti-neutrophil cytoplasmic antibody-associated systemic vasculitides. The dominant environmental risk factors appear to be silica exposure for all three syndromes, and vitamin D deficiency is strongly suggested by the latitude and ultraviolet radiation gradient observed for Wegener's granulomatosis and Churg-Strauss syndrome. Genetic factors are generally not very strong, consistent with the rarity of these conditions in...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Internal Medicine Journal
DOI: 10.1111/j.1445-5994.2011.02705.x


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