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Diannexin, a Novel Annexin V Homodimer, Provides Prolonged Protection Against Hepatic Ischemia-Reperfusion Injury in Mice

Teoh, Narcissus; Ito, Yoshiya; Field, Jacqueline; Bethea, Nancy W.; Amr, Deama; McCuskey, Margaret K.; McCuskey, Robert; Farrell, Geoffrey; Allison, Anthony C


Background & Aims: Ischemia-reperfusion injury (IRI) remains an important cause of liver failure after hepatic surgery or transplantation. The mechanism seems to originate within the hepatic sinusoid, with damage to endothelial cells, an early, reproducible finding. Sinusoidal endothelial cells (SECs), damaged during reperfusion, activate and recruit inflammatory cells and platelets. We hypothesized that a recombinant human annexin V homodimer, Diannexin, would protect SECs from reperfusion...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Gastroenterology
DOI: 10.1053/j.gastro.2007.05.027


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