Skip navigation
Skip navigation

The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells

Keam, Simon P; Young, Paul E; McCorkindale, Alexandra L; Dang, Thurston H Y; Clancy, Jennifer; Humphreys, David T; Preiss, Thomas; Hutvagner, Gyorgy; Martin, David I K; Cropley, Jennifer E; Suter, Catherine M

Description

The Piwi-piRNA pathway is active in animal germ cells where its functions are required for germ cell maintenance and gamete differentiation. Piwi proteins and piRNAs have been detected outside germline tissue in multiple phyla, but activity of the pathway in mammalian somatic cells has been little explored. In particular, Piwi expression has been observed in cancer cells, but nothing is known about the piRNA partners or the function of the system in these cells. We have surveyed the expression...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/26186
Source: Nucleic Acids Research
DOI: 10.1093/nar/gku620

Download

File Description SizeFormat Image
01_Keam_The_human_Piwi_protein_Hiwi2_2014.pdf181.57 kBAdobe PDF    Request a copy
02_Keam_The_human_Piwi_protein_Hiwi2_2014.pdf4.16 MBAdobe PDF    Request a copy
03_Keam_The_human_Piwi_protein_Hiwi2_2014.pdf4.16 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator