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L-arginine and vitamin D: novel immunotherapies in tuberculosis

Ralph, Anna; Kelly, Paul; Anstey, Nicholas


Worsening drug resistance and the need for prolonged treatment in tuberculosis (TB) require innovative solutions including investigation of inexpensive, safe adjunctive immunotherapies. L-arginine, the precursor of nitric oxide, and vitamin D recently have elucidated mycobactericidal and immunomodulatory actions against TB and are deficient in people with TB. We review the potential of these agents as adjunctive TB immunotherapies and explore how comparative clinical trials might help clarify...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Trends in Microbiology
DOI: 10.1016/j.tim.2008.04.003


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