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Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy.

Kole, Maarten; Letzkus, Johannes; Stuart, Gregory J


Action potentials are binary signals that transmit information via their rate and temporal pattern. In this context, the axon is thought of as a transmission line, devoid of a role in neuronal computation. Here, we show a highly localized role of axonal Kv1 potassium channels in shaping the action potential waveform in the axon initial segment (AIS) of layer 5 pyramidal neurons independent of the soma. Cell-attached recordings revealed a 10-fold increase in Kv1 channel density over the first 50...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Neuron
DOI: 10.1016/j.neuron.2007.07.031


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