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In situ reactions of monoclonal antibodies with a viable mutant of Murray Valley encephalitis virus reveal an absence of dimeric NS1 protein

Clark, David C; Lobigs, Mario; Lee, Eva; Howard, Megan J.; Clark, Kerri; Blitvich, Bradley J.; Hall, Roy A


Studies on the NS1 protein of flaviviruses have concluded that formation of a stable homodimer is required for virus replication. However, previous work has reported that substitution of a conserved proline by leucine at residue 250 in NS1 of Kunjin virus (KUNV) eliminated dimerization, but allowed virus replication to continue. To assess whether this substitution has similar effects on other flaviviruses, it was introduced into an infectious clone of Murray Valley encephalitis virus (MVEV)....[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/vir.0.82609-0


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