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Inherited cortical HCN1 loss amplifies dendritic calcium electrogenesis and burst firing in an rat absence epilepsy model

Kole, Maarten; Brauer, Anja U; Stuart, Gregory J


While idiopathic generalized epilepsies are thought to evolve from temporal highly synchronized oscillations between thalamic and cortical networks, their cellular basis remains poorly understood. Here we show in a genetic rat model of absence epilepsy (WAG/Rij) that a rapid decline in expression of hyperpolarization-activated cyclic-nucleotide gated (HCN1) channels (Ih) precedes the onset of seizures, suggesting that the loss of HCN1 channel expression is inherited rather than acquired. Loss...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2006.122028


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