Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal
Engelthaler, David M; Hicks, Nathan D; Gillece, John D; Roe, Chandler C; Schupp, James M; Driebe, Elizabeth M.; Gilgado, Felix; Carriconde, Fabian; Trilles, Luciana; Firacative, Carolina; Perez-Bercoff, Asa; Huttley, Gavin Austin
The emergence of distinct populations of Cryptococcus gattii in the temperate North American Pacific Northwest (PNW) was surprising, as this species was previously thought to be confined to tropical and semitropical regions. Beyond a new habitat niche, the dominant emergent population displayed increased virulence and caused primary pulmonary disease, as opposed to the predominantly neurologic disease seen previously elsewhere. Whole-genome sequencing was performed on 118 C. gattii isolates,...[Show more]
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