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Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal

Engelthaler, David M; Hicks, Nathan D; Gillece, John D; Roe, Chandler C; Schupp, James M; Driebe, Elizabeth M.; Gilgado, Felix; Carriconde, Fabian; Trilles, Luciana; Firacative, Carolina; Perez-Bercoff, Asa; Huttley, Gavin Austin

Description

The emergence of distinct populations of Cryptococcus gattii in the temperate North American Pacific Northwest (PNW) was surprising, as this species was previously thought to be confined to tropical and semitropical regions. Beyond a new habitat niche, the dominant emergent population displayed increased virulence and caused primary pulmonary disease, as opposed to the predominantly neurologic disease seen previously elsewhere. Whole-genome sequencing was performed on 118 C. gattii isolates,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/25859
Source: mBio
DOI: 10.1128/mBio.01464-14

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