Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy
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Naruse, Katsuhiko; Innes, Barbara; Bulmer, Judith; Robson, Stephen; Searle, Roger F; Lash, Gendie
Description
Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFNγ, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1β, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined...[Show more]
dc.contributor.author | Naruse, Katsuhiko | |
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dc.contributor.author | Innes, Barbara | |
dc.contributor.author | Bulmer, Judith | |
dc.contributor.author | Robson, Stephen | |
dc.contributor.author | Searle, Roger F | |
dc.contributor.author | Lash, Gendie | |
dc.date.accessioned | 2022-01-17T03:02:27Z | |
dc.identifier.issn | 0165-0378 | |
dc.identifier.uri | http://hdl.handle.net/1885/258444 | |
dc.description.abstract | Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFNγ, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1β, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined were detectable in the samples studied (n = 10 each group). Villous cytotrophoblast production of IL-1β and IL-8 increased with gestational age. Extravillous trophoblast production of IL-8, IL-13 and RANTES increased with gestational age. At 12–14 weeks gestation extravillous trophoblast cells secreted higher levels of IL-8, IL-13 and RANTES than villous cytotrophoblast cells. | |
dc.description.sponsorship | This project was supported by funding from BBSRC (S19967). | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Elsevier BV | |
dc.rights | © 2010 The Authors | |
dc.source | Journal of Reproductive Immunology | |
dc.subject | Extravillous trophoblast | |
dc.subject | Cytotrophoblast | |
dc.subject | Cytokines | |
dc.subject | First trimester pregnancy | |
dc.title | Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 86 | |
dc.date.issued | 2010 | |
local.identifier.absfor | 111402 - Obstetrics and Gynaecology | |
local.identifier.ariespublication | U3488905xPUB24019 | |
local.publisher.url | https://www.sciencedirect.com/science/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Naruse, Katsuhiko, Newcastle University | |
local.contributor.affiliation | Innes, Barbara, Newcastle University | |
local.contributor.affiliation | Bulmer, Judith, Newcastle University | |
local.contributor.affiliation | Robson, Stephen, College of Health and Medicine, ANU | |
local.contributor.affiliation | Searle, Roger F, Newcastle University | |
local.contributor.affiliation | Lash, Gendie, Newcastle University | |
local.description.embargo | 2099-12-31 | |
local.bibliographicCitation.issue | 2 | |
local.bibliographicCitation.startpage | 148 | |
local.bibliographicCitation.lastpage | 150 | |
local.identifier.doi | 10.1016/j.jri.2010.04.004 | |
dc.date.updated | 2020-12-06T07:20:47Z | |
local.identifier.scopusID | 2-s2.0-77957285601 | |
local.identifier.thomsonID | 000283901200066 | |
Collections | ANU Research Publications |
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