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Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy

Naruse, Katsuhiko; Innes, Barbara; Bulmer, Judith; Robson, Stephen; Searle, Roger F; Lash, Gendie


Cytokines are proposed to play roles in regulation of trophoblast invasion, spiral artery remodeling and immunoregulation during early pregnancy. Secretion of 12 cytokines (interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70, IL-13, IFNγ, GM-CSF, MCP-1 and RANTES) by first trimester extravillous trophoblast and villous cytotrophoblast cells was examined using multiplex cytokine array technology. Seven (IL-1β, IL-8, IL-12p70, IL-13, GM-CSF, MCP-1 and RANTES) of the 12 cytokines examined...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Reproductive Immunology
DOI: 10.1016/j.jri.2010.04.004


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