Skip navigation
Skip navigation

Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age

Lash, Gendie; Otun, Harry; Innes, Barbara; Percival, Kathryn; Searle, Roger F; Robson, Stephen; Bulmer, Judith


BACKGROUND Extravillous trophoblast (EVT) cell invasion of uterine decidua and the inner third of myometrium is critical for successful pregnancy. Many decidual factors are likely to play a role in regulating this process. We have previously shown that cytokines, known to be produced by uterine natural killer (uNK) cells, such as TNF-α, TGF-β1 and IFN-γ inhibit EVT invasion. We therefore hypothesized that supernatants from purified uNK cells would inhibit EVT invasion. METHODS AND...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Human Reproduction
DOI: 10.1093/humrep/deq050


File Description SizeFormat Image
01_Lash_Regulation_of_extravillous_2010.pdf472.27 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator