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Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age

Lash, Gendie; Otun, Harry; Innes, Barbara; Percival, Kathryn; Searle, Roger F; Robson, Stephen; Bulmer, Judith

Description

BACKGROUND Extravillous trophoblast (EVT) cell invasion of uterine decidua and the inner third of myometrium is critical for successful pregnancy. Many decidual factors are likely to play a role in regulating this process. We have previously shown that cytokines, known to be produced by uterine natural killer (uNK) cells, such as TNF-α, TGF-β1 and IFN-γ inhibit EVT invasion. We therefore hypothesized that supernatants from purified uNK cells would inhibit EVT invasion. METHODS AND...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/258438
Source: Human Reproduction
DOI: 10.1093/humrep/deq050

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