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Junction and triadin each active skeletal ryanodine receptors but junction alone mediates functional interactions with calsequestrin

Wei, Lan; Gallant, Esther; Dulhunty, Angela; Beard, Nicole

Description

Normal Ca2+ signalling in skeletal muscle depends on the membrane associated proteins triadin and junctin and their ability to mediate functional interactions between the Ca2+ binding protein calsequestrin and the type 1 ryanodine receptor in the lumen of the sarcoplasmic reticulum. This important mechanism conserves intracellular Ca2+ stores, but is poorly understood. Triadin and junctin share similar structures and are lumped together in models of interactions between skeletal muscle...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/25770
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2009.04.017

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