Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1
Warntges, Simone; Friedrich, Bjorn; Henke, Guido; Duranton, Christophe; Lang, P A; Waldegger, S; Meyermann, R; Kuhl, D; Speckmann, EJ; Obermuller, N; Broer, Stefan; Witzgall, R.; Mack, A.F.; Wagner, H.J; Wagner, Carsten; Lang, Florian
The serum- and glucocorticoid-dependent kinase SGK1 is regulated by alterations of cell volume, whereby cell shrinkage increases and cell swelling decreases the transcription, expression and activity of SGK1. The kinase is expressed in all human tissues studied including the brain. The present study was performed to localize the sites of SGK1 transcription in the brain, to elucidate the influence of the hydration status on SGK1 transcription and to explore the functional significance of altered...[Show more]
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