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Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1

Warntges, Simone; Friedrich, Bjorn; Henke, Guido; Duranton, Christophe; Lang, P A; Waldegger, S; Meyermann, R; Kuhl, D; Speckmann, EJ; Obermuller, N; Broer, Stefan; Witzgall, R.; Mack, A.F.; Wagner, H.J; Wagner, Carsten; Lang, Florian


The serum- and glucocorticoid-dependent kinase SGK1 is regulated by alterations of cell volume, whereby cell shrinkage increases and cell swelling decreases the transcription, expression and activity of SGK1. The kinase is expressed in all human tissues studied including the brain. The present study was performed to localize the sites of SGK1 transcription in the brain, to elucidate the influence of the hydration status on SGK1 transcription and to explore the functional significance of altered...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Pflugers Archives European Journal of Physiology
DOI: 10.1007/s00424-001-0737-1


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