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Transforming growth factor beta (TGFβ) plays a crucial role in prolonging allograft survival in an allodepletion ("pruning") skin transplant model

Watson, Debbie; Zhang, Geoff Yu; Hu, Min; Wang, Yuan-Min; Fletcher, Jeffery; Sartor, Mary; Alexander, Stephen

Description

Adoptive cell therapies involving cell manipulation to achieve tolerance are increasingly being studied in animal models and in human trials. We have demonstrated that the specific removal of allo-stimulated dividing cells (or "pruning") promotes long-term allograft survival across a major MHC mismatch in transplant models including skin, heart and islet transplants. In this study, we examine the role of transforming growth factor beta (TGFβ), an important regulatory cytokine, on allograft...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/25598
Source: Transplant Immunology
DOI: 10.1016/j.trim.2014.03.002

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