Environmental, personal and genetic determinants of response to vitamin D supplementation in older adults
Waterhouse, Mary; Tran, Bich; Armstrong, Bruce K; Baxter, Catherine; Ebeling, Peter; English, Dallas R; Gebski, Val; Hill, Christine; Kimlin, Michael; Venn, Alison; Webb, Penelope M; Whiteman, David C; Neale, Rachel; Lucas, Robyn
Context and Objective: Suboptimal vitamin D status can be corrected by vitamin D supplementation, but individual responses to supplementation vary. We aimed to examine genetic and nongenetic determinants of change in serum 25-hydroxyvitamin D (25(OH)D) after supplementation. Design and Participants: We used data from a pilot randomized controlled trial in which 644 adults aged 60 to 84 years were randomly assigned to monthly doses of placebo, 30 000 IU, or 60 000 IU vitamin D3 for 12 months....[Show more]
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|Source:||Journal of Clinical Endocrinology and Metabolism|
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