Small-Molecule Inhibition of PRMT5 Induces Translational Stress and p53 in JAK2V617F Mutant Myeloproliferative Neoplasms
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Sonderegger, Stefan; Cerruti, Loretta; Tremblay, Cedric; Toulmin, Emma; Saw, Jesslyn; Nebl, Thomas; Hannan, Katherine; Lane, Steven W.; Falk, Hendrik; Unnikrishnan, Ashwin; Stupple, Paul
Description
Background: Myeloproliferative neoplasms (MPN) are a diverse group of hematopoietic stem cell disorders. JAK2V617F gain-of-function is the most prevalent mutation, accounting for more than 60% of MPNs. PRMT5 was initially identified as a JAK-binding protein. Its enzymatic function catalyses the symmetric di-methylation of arginine on a variety of substrates, including histones and proteins of the splicing apparatus. It has been proposed that mutant JAK2 can phosphorylate PRMT5, leading to loss...[Show more]
Collections | ANU Research Publications |
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Date published: | 2018 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/254495 |
Source: | Blood |
DOI: | 10.1182/blood-2018-99-118406 |
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