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Influence of rBAT-Mediated Amino Acid Transport on Cytosolic pH

Moschen, I; Setiawan, Iwan; Palacin, Manuel; Broer, Stefan; Albers, Alexandra; Lang, Florian


rBAT, together with its subunit b0,+ AT mediates the hetero- and homoexchange of neutral and dibasic amino acids. Since the heteroexchange of dibasic amino acids against neutral amino acids is coupled to net transport of positive charge, this transport is electrogenic. Extracellular addition of histidine could create an inward or an outward current depending on extracellular pH (pHe) and cell membrane potential. It has been concluded that histidine may be transported in both its protonated and...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Nephron Journals, The
DOI: 10.1159/000065024


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