A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli
Nolan, Christopher; Roduit, Raphael; Alarcon, Cristina; Moore, Patrick; Barbeau, Annie; Delghingaro-Augusto, Viviane; Przybykowski, Ewa; Morin, Johane; Masse, Frederic; Massie, Bernard; Ruderman, Neil; Rhodes, Christopher; Poitout, Vincent; Prentki, Marc
The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid oxidation, thereby increasing the availability of LC-CoA for lipid signaling to cellular processes involved in exocytosis. For directly testing the model, INSr3 cell clones overexpressing malonyl-CoA decarboxylase in the cytosol (MCDc) in a tetracycline regulatable manner were generated, and INS(832/13) and rat islets were...[Show more]
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