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Multidrug efflux pumps: drug binding - gates or cavity?

Crowley, Emily; Callaghan, Richard


The role of the ATP-binding cassette ABCB1 in mediating the resistance to chemotherapy in many forms of cancer has been well established. The protein is also endogenously expressed in numerous barrier and excretory tissues, thereby regulating or impacting on drug pharmacokinetic profiles. Given these prominent roles in health and disease, a great deal of biochemical, structural and pharmacological research has been directed towards modulating its activity. Despite the effort, only a small...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: The FEBS Journal
DOI: 10.1111/j.1742-4658.2009.07484.x


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