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Patterns of indirect protein interactions suggest a spatial organization to metabolism

Perez-Bercoff, Asa; McLysaght, A; Conant, Gavin C


It has long been believed that cells organize their cytoplasm so as to efficiently channel metabolites between sequential enzymes. This metabolic channeling has the potential to yield higher metabolic fluxes as well as better regulatory control over metabolism. One mechanism for achieving such channeling is to ensure that sequential enzymes in a pathway are physically close to each other in the cell. We present evidence that indirect protein interactions between related enzymes represent a...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Molecular BioSystems
DOI: 10.1039/c1mb05168g


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