Poxvirus-Encoded Gamma Interferon Binding Protein Dampens the Host Immune Response to Infection
Ectromelia virus (ECTV), a natural mouse pathogen and the causative agent of mousepox, is closely related to variola virus (VARV), which causes smallpox in humans. Mousepox is an excellent surrogate small-animal model for smallpox. Both ECTV and VARV encode a multitude of host response modifiers that target components of the immune system and that are thought to contribute to the high mortality rates associated with infection. Like VARV, ECTV encodes a protein homologous to the ectodomain of...[Show more]
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|Source:||Journal of Virology|
|01_Sakala_Poxvirus-Encoded_Gamma_2007.pdf||291.96 kB||Adobe PDF||Request a copy|
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