Sakala, Isaac; Chaudhri, Geeta; Buller, R Mark; Nuara, Anthony A.; Bai, Hongdong; Chen, Nanhai; Karupiah, Gunasegaran
Ectromelia virus (ECTV), a natural mouse pathogen and the causative agent of mousepox, is closely related to variola virus (VARV), which causes smallpox in humans. Mousepox is an excellent surrogate small-animal model for smallpox. Both ECTV and VARV encode a multitude of host response modifiers that target components of the immune system and that are thought to contribute to the high mortality rates associated with infection. Like VARV, ECTV encodes a protein homologous to the ectodomain of...[Show more]
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