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Generating Inhibitors of P-Glycoprotein: Where to, Now?

Crowley, Emily; McDevitt, Christopher A.; Callaghan, Richard


The prominent role for the drug efflux pump ABCB1 (P-glycoprotein) in mediating resistance to chemotherapy was first suggested in 1976 and sparked an incredible drive to restore the efficacy of anticancer drugs. Achieving this goal seemed inevitable in 1982 when a series of calcium channel blockers were demonstrated to restore the efficacy of chemotherapy agents. A large number of other compounds have since been demonstrated to restore chemotherapeutic sensitivity in cancer cells or tissues....[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Methods in Molecular Biology
DOI: 10.1007/978-1-60761-416-6_18


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