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Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology

Burgio, Gaetan

Description

The generation of genetically modified alleles in mice using conventional transgenesis technologies is a long and inefficient process. A new study shows that the in situ delivery of CRISPR/Cas9 reagents into pregnant mice results in a high efficiency of editing, and enables the rapid generation of both simple and complex alleles.

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/251973
Source: Genome Biology
DOI: 10.1186/s13059-018-1409-1
Access Rights: Open Access

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