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Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics

Watson, Emma E; Liu, Xuyu; Thompson, Robert E; Ripoll-Rozada, Jorge; Wu, Mike; Alwis, Imala; Gori, Alessandro; Loh, Choy; Parker, Benjamin; Otting, Gottfried; Jackson, Shaun; Pereira, Pedro José Barbosa


The anophelins are small protein thrombin inhibitors that are produced in the salivary glands of the Anopheles mosquito to fulfill a vital role in blood feeding. A bioinformatic analysis of anophelin sequences revealed the presence of conserved tyrosine residues in an acidic environment that were predicted to be post-translationally sulfated in vivo. To test this prediction, insect cell expression of two anophelin proteins, from Anopheles albimanus and Anopheles gambiae, was performed, followed...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: ACS Central Science
DOI: 10.1021/acscentsci.7b00612
Access Rights: Open Access


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