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Using Micro-CT scanning to identify structural changes in Craniofacial, Neural, and Cardiovascular systems of spotting-lethal rat, a model of Hirschsprung disease

Chen, Ko-Chin


HSCR has long been regarded as an enteric disease for its well-known colonic aganglionosis. However, the fact of it being a polygenic neurocristopathy begs the question: is structural growth retardation a more general feature in HSCR individuals? To clarify, we examine the multi-organ changes within the sl/sl rat, which is an autosomal recessive HSCR model with high genetic penetrance that arises from ETB knockout mutation. This thesis contributes to improving our understanding in modified...[Show more]

CollectionsOpen Access Theses
Date published: 2022
Type: Thesis (PhD)
DOI: 10.25911/AAP0-TX38


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