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Landscape of DNA methylation on the marsupial x

Waters, Shafagh A.; Livernois, Alexandra M.; Patel, Hardip; O’Meally, Denis; Craig, Jeff; Graves, Jennifer A. Marshall; Suter, Catherine M; Waters, Paul D.

Description

DNA methylation plays a key role in maintaining transcriptional silence on the inactive X chromosome of eutherian mammals. Beyond eutherians, there are limited genome wide data on DNA methylation from other vertebrates. Previous studies of X borne genes in various marsupial models revealed no differential DNA methylation of promoters between the sexes, leading to the conclusion that CpG methylation plays no role in marsupial X-inactivation. Using reduced representation bisulfite sequencing, we...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/251732
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/msx297
Access Rights: Open Access

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