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Laboratory evolution of protein conformational dynamics

Campbell, Eleanor; Correy, Galen; Mabbitt, Peter; Buckle, Ashley; Tokiriki, Nobuhiko; Jackson, Colin

Description

This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/251716
Source: Current Opinion in Structural Biology
DOI: 10.1016/j.sbi.2017.09.005

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