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Atypical chemokine receptor 4 shapes activated B cell fate

Kara, Ervin; Bastow, Cameron R; McKenzie, Duncan R; Gregor, Carly E; Fenix, Kevin A; Babb, Rachelle; Norton, Todd S; Zotos, Dimitra; Rodda, Lauren B; Hermes, Jana R; Bourne, Katherine; Gilchrist, Derek S; Alsharifi, Mohammed; Vinuesa, Carola


Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood. Here, we identify atypical chemokine receptor 4 (ACKR4), a decoy receptor that binds and degrades CCR7 ligands CCL19/CCL21, as a regulator of early activated B cell differentiation. By restricting initial access to splenic interfollicular zones (IFZs), ACKR4 limits the early proliferation...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20171067
Access Rights: Open Access


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