A potential new, stable state of the E-cadherin strand-swapped dimer in solution
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Schumann-Gillett, Alexandra; Mark, Alan E.; Deplazes, Evelyne; O'Mara, Megan
Description
E-cadherin is a transmembrane glycoprotein that facilitates inter-cellular adhesion in the epithelium. The ectodomain of the native structure is comprised of five repeated immunoglobulin-like domains. All E-cadherin crystal structures show the protein in one of three alternative conformations: a monomer, a strand-swapped trans homodimer and the so-called X-dimer, which is proposed to be a kinetic intermediate to forming the strand-swapped trans homodimer. However, previous studies have...[Show more]
Collections | ANU Research Publications |
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Date published: | 2018 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/250878 |
Source: | European Biophysics Journal |
DOI: | 10.1007/s00249-017-1229-3 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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211015 - E-cad_revision2_main_text_FINAL_cleaned.pdf | Author accepted manuscript | 572.71 kB | Adobe PDF | Request a copy |
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