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Variation within MBP gene predicts disease course in multiple sclerosis

Zhou, Yuan; Simpson Jr, S; Charlesworth, Jac C; Van Der Mei, Ingrid; Lucas, Robyn; Taylor, B V; Dear, Keith; Ponsonby, Anne-Louise; Dwyer, Terry

Description

Objective: Prognosis following a first demyelinating event is difficult to predict, with no genetic markers of MS progression currently identified. Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome-wide association studies. We hypothesized that genetic variations in MBP may be a determinant of MS clinical...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/250758
Source: Brain and Behavior
DOI: 10.1002/brb3.670
Access Rights: Open Access

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