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Unconventional pro-inflammatory CD4+ T cell response in B cell-deficient mice infected with Trypanosoma cruzi

Gorosito, Melisa; Tosello Boari, Jimena; Fiocca Vernengo, Facundo; Beccaria, Cristian G; Ramello, Maria C; Bermejo, Daniela A; Cook, Amelia; Garcia De Vinuesa, Maria Carola; Montes, Carolina L; Acosta Rodriguez, Eva V; Gruppi, Adriana


Chagas disease, caused by the parasite Trypanosoma cruzi, is endemic in Latin America but has become a global public health concern by migration of infected people. It has been reported that parasite persistence as well as the intensity of the inflammatory immune response are determinants of the clinical manifestations of the disease. Even though inflammation is indispensable for host defense, when deregulated, it can contribute to tissue injury and organ dysfunction. Here, we report the...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01548
Access Rights: Open Access


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