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TRPA1 expression and its functional activation in rodent cortex

Kheradpezhouh, Ehsan; Choy, Julian; Daria, Vincent; Arabzadeh, Ehsan


TRPA1 is a non-selective cation channel involved in pain sensation and neurogenic inflammation. Although TRPA1 is well established in a number of organs including the nervous system, its presence and function in the mammalian cortex remains unclear. Here, we demonstrate the expression of TRPA1 in rodent somatosensory cortex through immunostaining and investigate its functional activation by whole-cell electrophysiology, Ca2+ imaging and two-photon photoswitching. Application of TRPA1 agonist...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Open Biology
DOI: 10.1098/rsob.160314
Access Rights: Open Access


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