Towards the structure of the TIR-domain signalosome
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Nimma, Surekha; Ve, Thomas; Williams, Simon; Kobe, Bostjan
Description
TIR (Toll/interleukin-1 receptor/resistance protein) domains feature in animal, plant and bacterial proteins involved in innate immunity pathways and associated processes. They function through protein:protein interactions, in particular self-association and homotypic association with other TIR domains. Structures of TIR domains from all phyla have been determined, but common association modes have only emerged for plant and bacterial TIR domains, and not for mammalian TIR domains. Numerous...[Show more]
dc.contributor.author | Nimma, Surekha | |
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dc.contributor.author | Ve, Thomas | |
dc.contributor.author | Williams, Simon | |
dc.contributor.author | Kobe, Bostjan | |
dc.date.accessioned | 2021-10-07T23:20:38Z | |
dc.identifier.issn | 0959-440X | |
dc.identifier.uri | http://hdl.handle.net/1885/250555 | |
dc.description.abstract | TIR (Toll/interleukin-1 receptor/resistance protein) domains feature in animal, plant and bacterial proteins involved in innate immunity pathways and associated processes. They function through protein:protein interactions, in particular self-association and homotypic association with other TIR domains. Structures of TIR domains from all phyla have been determined, but common association modes have only emerged for plant and bacterial TIR domains, and not for mammalian TIR domains. Numerous attempts involving hybrid approaches, which have combined structural, computational, mutagenesis and biophysical data, have failed to converge onto common models of how these domains associate and function. We propose that the available data can be reconciled in the context of higher-order assembly formation, and that TIR domains function through signaling by cooperative assembly formation (SCAF). | |
dc.description.sponsorship | The work in the authors’ laboratories was supported by the National Health and Medical Research Council (NHMRC grants 1003326, 1107804, 1071659) and the Australian Research Council (ARC Discovery Projects DP120100685, DP160102244). BK is NHMRC Principal Research Fellow (1003325, 1110971). Simon Williams is funded by ARC DECRA (DE160100893). We acknowledge the use of the University of Queensland Remote Operation Crystallization and X-ray Diffraction Facility (UQ ROCX) and the Australian Synchrotron (MX and SAXSWAXS beamlines) for our structural work. | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Elsevier | |
dc.rights | © 2017 Elsevier Ltd | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Current Opinion in Structural Biology | |
dc.title | Towards the structure of the TIR-domain signalosome | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 43 | |
dc.date.issued | 2017 | |
local.identifier.absfor | 060112 - Structural Biology (incl. Macromolecular Modelling) | |
local.identifier.ariespublication | u4956746xPUB631 | |
local.publisher.url | https://www.elsevier.com/en-au | |
local.type.status | Accepted Version | |
local.contributor.affiliation | Nimma, Surekha, University of Queensland | |
local.contributor.affiliation | Ve, Thomas , University of Queensland | |
local.contributor.affiliation | Williams, Simon, College of Science, ANU | |
local.contributor.affiliation | Kobe, Bostjan, University of Queensland | |
dc.relation | http://purl.org/au-research/grants/arc/DP120100685 | |
dc.relation | http://purl.org/au-research/grants/arc/DP160102244 | |
dc.relation | http://purl.org/au-research/grants/arc/DE160100893 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1003326 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1107804 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1071659 | |
local.bibliographicCitation.issue | 1 | |
local.bibliographicCitation.startpage | 122 | |
local.bibliographicCitation.lastpage | 130 | |
local.identifier.doi | 10.1016/j.sbi.2016.12.014 | |
local.identifier.absseo | 970106 - Expanding Knowledge in the Biological Sciences | |
dc.date.updated | 2020-11-23T11:23:21Z | |
local.identifier.scopusID | 2-s2.0-85009165959 | |
local.identifier.thomsonID | 000403460500017 | |
dcterms.accessRights | Open Access | |
dc.provenance | https://v2.sherpa.ac.uk/id/publication/11158..."The Accepted Version can be archived in an Institutional Repository. 12 Months. CC BY-NC-ND." from SHERPA/RoMEO site (as at 11/10/2021). | |
dc.rights.license | CC BY-NC-ND | |
Collections | ANU Research Publications |
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