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Towards the structure of the TIR-domain signalosome

Nimma, Surekha; Ve, Thomas; Williams, Simon; Kobe, Bostjan


TIR (Toll/interleukin-1 receptor/resistance protein) domains feature in animal, plant and bacterial proteins involved in innate immunity pathways and associated processes. They function through protein:protein interactions, in particular self-association and homotypic association with other TIR domains. Structures of TIR domains from all phyla have been determined, but common association modes have only emerged for plant and bacterial TIR domains, and not for mammalian TIR domains. Numerous...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Current Opinion in Structural Biology
DOI: 10.1016/
Access Rights: Open Access


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