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TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival

Mridha, Auvro; Haczeyni, Fahrettin; Yeh, Matthew; Haigh, W Geoffrey; Ioannou, George; Barn, Vanessa; Ajamieh, Hussam; Adams, Leon Anton; Hamdorf, Jeffrey M; Teoh, Narcissus; Farrell, Geoffrey


Background and aims: TLR9 deletion protects against steatohepatitis due to choline-amino acid depletion and high-fat diet. We measured TLR9 in human non-alcoholic steatohepatitis (NASH) livers, and tested whether TLR9 mediates inflammatory recruitment in three murine models of non-alcoholic fatty liver disease (NAFLD). Methods: We assayed TLR mRNA in liver biopsies from bariatric surgery patients. Wild-type (Wt), appetite-dysregulated Alms1 mutant (foz/foz), Tlr9-/-, and Tlr9-/-.foz/foz...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: Clinical Science
DOI: 10.1042/CS20160838


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