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Therapeutic Approaches Targeting MYC-Driven Prostate Cancer

Rebello, Richard J; Pearson, Richard B; Hannan, Ross; Furic, Luc


The transcript encoding the proto-oncogene MYC is commonly overexpressed in prostate cancer (PC). MYC protein abundance is also increased in the majority of cases of advanced and metastatic castrate-resistant PC (mCRPC). Accordingly, the MYC-directed transcriptional program directly contributes to PC by upregulating the expression of a number of pro-tumorigenic factors involved in cell growth and proliferation. A key cellular process downstream of MYC activity is the regulation of ribosome...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: GENES
DOI: 10.3390/genes8020071
Access Rights: Open Access


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