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Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

Gresle, M M; Liu, Y; Dagley, L F; Haartsen, J; Pearson, F; Purcell, A W; Laverick, L; Petzold, A; Van der Walt, A; Prime, H; Morris, D R; Taylor, Bruce V; Shaw, G; Butzkueven, Helmut; Lucas, Robyn


Objectives: We evaluated whether the measurement of serum phosphorylated neurofilament heavy chain (pNF-H) titre is likely to be a valid biomarker of axonal injury in multiple sclerosis (MS). Methods: Serum pNF-H concentrations were measured by ELISA in cases with relapsing-remitting (RR)-MS (n=81), secondary progressive (SP) MS (n=13) and primary progressive (PP)-MS; n=6) MS; first demyelinating event (FDE; n=82); and unaffected controls (n=135). A subset of MS cases (n=45) were re-sampled on...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Neurology, Neurosurgery & Psychiatry
DOI: 10.1136/jnnp-2013-306789


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