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The potential of targeting ribosome biogenesis in high-grade serous ovarian cancer

Yan, Shunfei; Frank, Daniel; Son, Jinbae; Hannan, Katherine; Hannan, Ross; Chan, Keefe; Pearson, Richard B; Sanij, Elaine


Overall survival for patients with ovarian cancer (OC) has shown little improvement for decades meaning new therapeutic options are critical. OC comprises multiple histological subtypes, of which the most common and aggressive subtype is high-grade serous ovarian cancer (HGSOC). HGSOC is characterized by genomic structural variations with relatively few recurrent somatic mutations or dominantly acting oncogenes that can be targeted for the development of novel therapies. However, deregulation...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
Source: International Journal of Molecular Sciences
DOI: 10.3390/ijms18010210
Access Rights: Open Access


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