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The PHF21B gene is associated with major depression and modulates the stress response

Wong, M.-L.; Arcos-Burgos, Mauricio; Liu, S.; Vélez, Jorge; Yu, C.; Baune, Bernhard; Jawahar, Magdalene Catharine; Arolt, V.; Dannlowsk, Udo; Chuah, Aaron; Huttley, Gavin; Licinio, Julio

Description

Major depressive disorder (MDD) affects around 350 million people worldwide; however, the underlying genetic basis remains largely unknown. In this study, we took into account that MDD is a gene-environment disorder, in which stress is a critical component, and used whole-genome screening of functional variants to investigate the ‘missing heritability’ in MDD. Genome-wide association studies (GWAS) using single- and multi-locus linear mixed-effect models were performed in a Los Angeles...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/249099
Source: Molecular Psychiatry
DOI: 10.1038/mp.2016.174
Access Rights: Open Access

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