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The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

Hapuarachchi, Sanduni; Cobbold, Simon A.; Shafik, Sarah; Dennis, Adelaide; McConville, Malcolm J; Martin, Rowena; Kirk, Kiaran; Lehane, Adele

Description

In this study the `Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidification of the parasite cytosol. Two of these did so by inhibiting the parasite's formate nitrite transporter (PfFNT), which mediates the H+-coupled efflux from the parasite of lactate generated by glycolysis. Both compounds were shown to inhibit lactate...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/249016
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1006180
Access Rights: Open Access

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