Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?
This review addresses the potential use of the intracellular ryanodine receptor (RyR) Ca2+ release channel as a therapeutic target in heart disease. Heart disease encompasses a wide range of conditions with the major contributors to mortality and morbidity being ischaemic heart disease and heart failure (HF). In addition there are many rare, but devastating conditions, some of which are either genetically linked to the RyR and its regulatory proteins or involve drug-induced modification of the...[Show more]
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|Source:||Pharmacology and Therapeutics|
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