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The influence of platelet membranes on tumour cell behaviour

Coupland, Lucy; Hindmarsh, Elizabeth; Gardiner, Elizabeth; Parish, Christopher

Description

The significant role of platelets in the protection of tumour cells from immune attack and shear forces and the promotion of tumour cell extravasation from the bloodstream in the process of haematogenous metastasis have been extensively studied. The role of platelets, and in particular platelet membranes, in the promotion of a more metastatic phenotype in tumour cells is a more recent and, therefore, less well-recognised area of research. This review article summarises studies that have focused...[Show more]

dc.contributor.authorCoupland, Lucy
dc.contributor.authorHindmarsh, Elizabeth
dc.contributor.authorGardiner, Elizabeth
dc.contributor.authorParish, Christopher
dc.date.accessioned2021-09-29T23:16:27Z
dc.identifier.issn0167-7659
dc.identifier.urihttp://hdl.handle.net/1885/248879
dc.description.abstractThe significant role of platelets in the protection of tumour cells from immune attack and shear forces and the promotion of tumour cell extravasation from the bloodstream in the process of haematogenous metastasis have been extensively studied. The role of platelets, and in particular platelet membranes, in the promotion of a more metastatic phenotype in tumour cells is a more recent and, therefore, less well-recognised area of research. This review article summarises studies that have focused on the impact of tumour cell interactions with platelets and platelet membranes on tumour cell behaviour in vitro and in vivo. Furthermore, the gene expression changes that occur within tumour cells following contact with platelet membranes are also extensively reviewed. Overall, the interaction of platelet membranes with tumour cells results in a more invasive phenotype and the promotion of epithelial to mesenchymal transition with our own genetic studies revealing that matrix metalloproteinase-1, plasminogen activator inhibitor-1 and interleukin-8 are globally upregulated in a range of tumour cell lines.
dc.description.sponsorshipThe authors acknowledge financial support from the National Health and Medical Research Council of Australia
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherKluwer Academic Publishers
dc.rights© Springer Science+Business Media, LLC 2017
dc.sourceCancer and Metastasis Reviews
dc.subjectPlatelets
dc.subjectPlatelet membranes
dc.subjectTumour
dc.subjectEMT
dc.subjectInvasion
dc.subjectMigration
dc.titleThe influence of platelet membranes on tumour cell behaviour
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume36
dc.date.issued2017
local.identifier.absfor111201 - Cancer Cell Biology
local.identifier.ariespublicationu6800332xPUB267
local.publisher.urlhttps://link.springer.com/
local.type.statusPublished Version
local.contributor.affiliationCoupland, Lucy, College of Health and Medicine, ANU
local.contributor.affiliationHindmarsh, Elizabeth, College of Health and Medicine, ANU
local.contributor.affiliationGardiner, Elizabeth, College of Health and Medicine, ANU
local.contributor.affiliationParish, Christopher, College of Health and Medicine, ANU
local.description.embargo2099-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage215
local.bibliographicCitation.lastpage224
local.identifier.doi10.1007/s10555-017-9671-3
dc.date.updated2020-11-23T11:17:44Z
local.identifier.scopusID2-s2.0-85023776376
local.identifier.thomsonID000407749300005
CollectionsANU Research Publications

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