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The biological and clinical significance of stromal-epithelial interactions in breast cancer

McCuaig, Robert; Wu, Fan; Dunn, J; Rao, Sudha; Dahlstrom, Jane

Description

There is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the...[Show more]

dc.contributor.authorMcCuaig, Robert
dc.contributor.authorWu, Fan
dc.contributor.authorDunn, J
dc.contributor.authorRao, Sudha
dc.contributor.authorDahlstrom, Jane
dc.date.accessioned2021-09-26T23:22:39Z
dc.date.available2021-09-26T23:22:39Z
dc.identifier.issn0031-3025
dc.identifier.urihttp://hdl.handle.net/1885/248730
dc.description.abstractThere is evidence that an aberrant tumour microenvironment (TME) facilitates cancer development, progression, and responses to treatment. While many of the mechanisms underlying the phenotype and cancer-promoting behaviour of the TME are unknown, epigenetic mechanisms in cancer cells and the TME are thought to play important roles. As a result, cancer profiling strategies for drug and biomarker development require a thorough understanding of both the epithelial tissue compartment and the TME. This review discusses recent advances in our understanding of how cancer epithelial cells interact with their microenvironment and how this knowledge can be exploited clinically.
dc.description.sponsorshipThe original research presented in this review was supported under NHMRC Projects funding scheme (project number APP1048065)
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherElsevier
dc.rights© 2016 Royal College of Pathologists of Australasia. Published by Elsevier B.V
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePathology
dc.subjectBreast cancer
dc.subjectepigenetics
dc.subjecttumour microenvironment
dc.subjectcancer stem cells
dc.subjectepi-drugs
dc.subjectcancer associated fibroblasts
dc.subjectDNA methylation
dc.subjecthistone
dc.titleThe biological and clinical significance of stromal-epithelial interactions in breast cancer
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume49
dc.date.issued2017
local.identifier.absfor111203 - Cancer Genetics
local.identifier.absfor111201 - Cancer Cell Biology
local.identifier.ariespublicationa383154xPUB4759
local.publisher.urlhttps://www.elsevier.com/en-au
local.type.statusPublished Version
local.contributor.affiliationMcCuaig, Robert, University of Canberra
local.contributor.affiliationWu, Fan, University of Canberra
local.contributor.affiliationDunn, J, University of Canberra
local.contributor.affiliationRao, Sudha, University of Canberra
local.contributor.affiliationDahlstrom, Jane, College of Health and Medicine, ANU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1048065
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage133
local.bibliographicCitation.lastpage140
local.identifier.doi10.1016/j.pathol.2016.10.009
dc.date.updated2020-11-23T11:14:48Z
local.identifier.scopusID2-s2.0-85009424643
local.identifier.thomsonID000397017200004
dcterms.accessRightsOpen Access
dc.provenanceThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.licenseCC BY license
CollectionsANU Research Publications

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